The Department of Internal Medicine is one of the core departments in Kulliyyah of Medicine. It provides teaching and clinical services as well as embarks on research activities related to general medicine and its various subspecialty disciplines. Teaching facilities and resources are appropriate and adequate, be it in Hospital Tengku Ampuan Afzan (HTAA), Jalan Hospital Campus, Indera Mahkota Campus or the newly established IIUM Medical Centre.

Since its inception, the Kulliyyah and the Department works closely with HTAA, in terms of teachings as well as clinical services. Good relationship and close cooperation and liaison between the staff of IIUM and HTAA enables the students to obtain the necessary knowledge and experience to be good medical practitioners. Ward-based teaching is conducted at HTAA, a 700-bedded state general hospital, as well as in IIUM Medical Centre. Classroom-based teachings are conducted at the seminar rooms or lecture halls in Jalan Hospital Campus or Indera Mahkota Campus, as well as the seminar room at MOPD, HTAA. All academic staff in the Department of Medicine has an office situated at the Kulliyyah of Medicine building in Jalan Hospital Campus.

IIUM Medical Centre, a newly completed 350-bedded teaching hospital, has started its operation since June 2016. Clinical services which have been up and running include general medicine in-patient care, intensive care, endoscopy services as well as medical specialist clinics which include cardiology, nephrology, neurology, endocrinology, respiratory medicine, gastroenterology, rheumatology and dermatology services. IIUM Dialysis Centre established Jun 2021 and now open for public. Teaching facilities available in the hospital include seminar rooms, auditorium, as well as examination ward.