Background

Pharmacognosy is a science that focuses on molecules and involves isolation and determination of the structure of pharmacologically active molecules as well as the study of their biosynthesis, including the enzymes and the genes which are involved. It is extended to a big data analysis to connect between bioactivity, metabolites, and drug sources. Our current performance is indicated as follows. 

Scope of Research Activities

1. Isolation and characterisation of bioactive compounds 
2. Metabolomics 
3. Bioactivity and toxicity studies 
4. Structure-activity relationship studies (SAR) 
5. Protein-ligand interaction studies 
6. Formulation of standardized extract 
7. Extract enhancement 
8. Quality control 

Leader and Members

• Assoc. Prof. Dr. Siti Zaiton (Leader)
• Assoc. Prof. Dr. Alfi Khatib
• Asst. Prof. Dr. Norazian bt Mohd Hasan
• Assoc. Prof. Dr. Qamar Uddin Ahmed
• Assoc. Prof. Dr. ABM Helal Uddin
• Asst. Prof. Dr. M. Jamshed A. Siddiqui
• Asst. Prof. Dr. Bisha Fathamah bt Uzir
• Asst Prof. Dr. Irna Elina binti Ridzwan
• Asst. Prof. Dr. Mohamed Sufian Bin Mohd Nawi
• Asst. Prof Dr. Zalikha Ibrahim
• Asst Prof. Dr. Awis Sukarni bin Mohmad  Sabere

Post Graduate Students (as Main Supervisor)

a. On-going (as main supervisor or chairman)

i. Ph.D students:

• Hussam Abdeljaber Ahmed Mizher (G1524417). Thesis title: Investigation of opioids tolerance and its association with blood and cytokine concentration in the plasma of patients with non-cancer pain receiving short and long term opioid therapy for pain management. Chairman: Assoc. Prof. Dr. ABM Helal Uddin.
• Nipun Tanzina Sharmin (G1710044). Thesis title: Evaluation of anti-diabetic activity of Psychotria malayana Jack leaves and characterization of its bioactive compounds using metabolomics and molecular docking simulation. Supervisor: Assoc. Prof. Dr. Alfi Khatib.
• Hidayatul Radziah binti Ismawi (G1517424). Ph. D. Medical Science. (KOM). Thesis Title: Post Partum Endothelin – 1 (ET-1) and Hypertensive Disorders of Pregnancy. Supervisor: Assoc. Prof. Dr. A. B. M. Helal Uddin.
• Mohammed S.M. Saleh (G152524). Thesis title: Phytochemical Profiling of Salak (Salacca Zalacca) Fruits Extracts through Metabolomics Approach and Investigations of their Antidiabetic and Antioxidant Potential In vitro, In silico and In vivo Studies. Supervisor: Asst. Prof. Mohammad Jamshed Siddiqui

ii. Master students:

• Nur Nadhirah binti Hilmi (G1624744). Thesis Title: Comparison of Volatile Aroma Constituents of Salacca zalacca (Gaertn.) Voss Fruit Extracted by Conventional and Non-Conventional Methods. Supervisor: Assoc. Prof. Dr. Siti Zaiton.
• Liyana Zafirah Binti Othman (G1623876). Thesis Title: Formulation and Analytical Method Development of Syariah Compliant Sustained Release Gliclazide Tablet. Supervisor: Assoc. Prof. Dr. ABM Helal Uddin.
• Ahmed Nokhala (G1810281). Thesis Title: Evaluation of α- Glucosidase Inhibitory Activity o f Tetracera scandens Extracts using Metabolomics Approach. Supervisor: Asst. Prof. Mohammad Jamshed Siddiqui.

b. Graduated (as main supervisor or chairman)

i. Ph.D – no.of students:

• Assoc. Prof. Dr. Siti Zaiton – 2
• Assoc. Prof. Dr. Alfi Khatib – 2
• Assoc. Prof. Dr. ABM Helal Uddin – 2
• Assoc. Prof. Dr. Qamar Uddin Ahmed – 2

ii. Master – no.of students:

• Assoc. Prof. Dr. Siti Zaiton – 2
• Asst. Prof Dr. Norazian – 4
• Assoc. Prof. Dr. Alfi – 2
• Assoc. Prof. Dr. ABM Helal Uddin – 5
• Assoc. Prof. Dr. Qamar Uddin Ahmed – 4
• Asst Prof Dr Mohammad Jamshed – 1
• Asst. Prof. Dr. Bisha Fathamah Uzir – 2
• Asst. Prof. Dr. Irna Elina binti Ridzwan – 2

Laboratories and Facilities

a. Laboratories: Analytical and Bioanalytical Research Lab 1, Analytical Chemistry Research Lab 2, Analytical Chemistry Research Lab 3, Medicinal and Organic Chemistry Research Lab, Pharmaceutical Chemistry Lab 2, Tissue Culture Lab, Herbal Lab.

b. Facilities: FTIR, GCMS, Analytical and Preparative HPLC, AAS, UV-Vis

Link and Collaboration

• MOU with Universitas Islam Indonesia,
• MOU with Universitas Airlangga
• MOU with International Medical University (IMU),
• MOU with Cyberjaya University College of Medical Sciences (CUCMS)
• MOU with UiTM

Community Services 

Education on Chemistry of Medicinal Plant – target group to IIUM community, government officers via e-buletin

Research Grant (as PI-on going)

• RIGS16-293-0457. Isolation, Identification and Computational Studies of α-Glucosidase Inhibitors from Clinacanthus nutans (Burm F.) Lindau Leaves Extracts. Amount: RM 20,000.00. PI: Asst. Prof Dr. Zalikha Ibrahim.
• SP17-002-0264. Analytical and Biological Activity Analysis of Malaysian leeches Saliva Extract of Both Green and Brown Types. BIOPEP Canada Inc. External Overseas grant. Amount :RM 70,000. PI: Assoc. Prof. Dr. A. B. M. Helal Uddin.
• RIGS16-292-0456. Influence of multiple reaction monitoring (MRM) on the separation of amlodipine and perindopril in pharmaceutical dosage form and plasma..Amount: RM 20,000. PI: Assoc. Prof. Dr. A. B. M. Helal Uddin.
• SP11-003-0071. Analytical method development for the detection and determination of amlodipine in pharmaceutical raw materials and dosage forms. Special fund from Ministry of Finance (MOF) Malaysia. Amount:RM 512,000. PI: Assoc. Prof. Dr. A. B.M. Helal Uddin.
• RIGS15-090-0090. Addressing Formulation Issues of Syariah Compliant Generic Sustained Release Antidiabetic Solid Dosage Form. Co Researcher. IIUM Amount: RM 28,000. PI: Asst. Prof. Dr. Mohamed Sufian Bin Mohd Nawi.
• P-RIGS18-027-0027. Identification of alpha-glucosidase inhibitors from P. malayana leaf extract using liquid chomatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking. Amount: RM 20,000. PI: Assoc. Prof. Dr. Alfi Khatib.
• RIGS 15-099-0099. Isolation of Alpha-Glucosidase Inhibitor and aroma from the Flesh of Salak (Salacca zalacca) Fruit and Their Metabolic Profiling on GC/MS. Amount:20,000. PI: Asst. Prof. Dr. M. Jamshed Siddiqui.

List of Selected Publications (1 selected publication for 1 lecturer)

● Roheem, Fatimah and Mat So’ad, Siti Zaiton and Ahmed, Qamar Uddin and Ali Shah, Syed Adnan and Latip, Jalifah and Zakaria, Zainul Amiruddin (2019). Evaluation of the enzyme inhibitory and antioxidant activities of Entada spiralis stem bark and isolation of the active constituents. Molecules. ISSN 1420-3049 

● Md. Mahmudul Hasan, Qamar Uddin Ahmed, Siti Zaiton Mat Soad, Tasnuva Sarwar Tunna. (2018). Animal models and natural products to investigate in vivo and in vitro antidiabetic activity. Biomedicine & Pharmacotherapy Vol. 101: 833-841. 

● Muhamad Faris, O., Norazian, M. H., Alfi, K. & Siti Marponga, T. (2018). Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions. Antioxidants, 7(11). 1-14. ISSN 2076-3921. 

● Murugesu, S., Ibrahim, Z., Qamar Uddin Ahmed, Uzir, B. F., Yusoff, N. I. N., Perumal, V., … & Khatib, A. (2018). Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking. Journal of Pharmaceutical Analysis (In Press).

● Ibrahim, Z., Tejo, B. A., Latif, M. A. M., Karjiban, R. A., Salleh, A. B. and Rahman, M. B. A. (2016). In-silico Identification of Potential Protein Arginine Deiminase IV (PAD4) Inhibitors, Malaysian Journal of Analytical Sciences, 20 (6), 1269-1277. 

● A.B.M. Helal Uddin, Mohamed Alaama, Mohamed b. Awang and S.A. Abbas (2018). Development and Validation of Bioanalytical Method for the Analysis of Amlodipine in Human Plasma with Optimized Extraction Method Using Design of Experiment. Latin American Journal of Pharmacy. Lat. Am. J. Pharm. 37 (1): 99-104. (ISI) 

● Suganya Murugesu, Zalikha Ibrahim, Qamar Uddin Ahmed, Nik Mohd. Idris Nik Yusoff, Bisha Fathamah Uzir, Vikneswari Perumal, Faridah Abas, …Hesham El-Seedi (2018). Characterization of αglucosidase inhibitors from clinacanthus nutans lindau Llaves by gas chromatography-mass spectrometry-based metabolomics and molecular docking simulation. Molecules, 23 (9). , 0 pp. 1-21. ISSN 1420-3049 

● Hariono, M., Choi, S. B., Roslim, R. F., Nawi, M. S., Tan, M. L., Kamarulzaman, E. E., Mohamed, N., Yusof, R., Othman, S., Rahman, N. A., Othman, R., Wahab, H. A. (2019). Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling. PLoS ONE, 14 (1). , 0 pp. 1-21. ISSN 1932-6203. 

● Mohammed S M Saleh, Dzatil Awanis Mohd Bukhari, Mohammad Jamshed Ahmad Siddiqui, Abdul Razak Kasmuri, Suganya Murugesu, Alfi Khatib (2019). GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity. Natural Product Research. , 0 ISSN 1478-641926

Extraction and Isolation Laboratory

Background

Substance Use Disorder (SUD) is a growing public health problem that occurs worldwide and yet there is still no concrete approach in curbing such predicament. The development of related studies especially on pharmacological interventions seems to be decelerated could be due to the lack of interest from the researchers or profit gained from this population. Patients with SUD are more than always received stigmas and negative perceptions form the community they lived in or even from the healthcare practitioners where this population has been associated with violence, crime, misbehaviour and threat to the community that impede healthcare delivery towards them.

Scope of Research Activities

• Evaluation on the actual burden of SUD disease in our country both for illicit (amphetamine, marijuana, ketum, etc) and prescription drugs.
• Longitudinal evaluation on the outcomes of current treatment approach (patient, community and national level).
• Investigation on the effectiveness of methadone maintenance therapy (MMT) program in this country as one of the harm reduction approaches.
• Identification of possible other treatment approach or strategy in the pipeline to be further developed (eg: PK/PD approach /opioid vaccine).
• Overviewing, proposing and improving current policy regarding SUD.
• Identify the potential drug target to treat poly-drug addiction using pharmacological approach.
• Identify potential compounds in local plants that can be developed to treat drug addiction.

Leader and Members

• Dr Nor Ilyani Mohamed Nazar. (Leader)
• Dr Che Suraya Haji Mohd Zin.
• Dr Mohamad Haniki Nik Mohamed.
• Dr Norny Syafinaz Ab Rahman.
• Dr Nor Hidayah Mohd Taufek.
• Dr Irna Elina Ridzwan.
• Mdm Siti Halimah Bux Shaikh Rahman Bux.
• Dr Wael Mohamed Yousef Mohamed (KOM)

Post Graduate Students in Masters in Pharmaceutical Sciences

• Muhamad Nazrin Syafiq b Khairi – Pharmacy Practice
• Aida Roziana bt Ramlan – Pharmacy Practice
• Maryam Saadah bt Suhaimi – Pharmacology
• Nur Syafinaz bt Wasli – Pharmacology

Laboratory(s) and facility(s)

Conditioned Place Preference Chamber (for rodents’ model) Conditioned Place Preference Chamber (for zebrafish’ model)

Link and Collaboration

• KOMITED Malaysia
• SOLACE Malaysia
• National Anti Drug Agency
• Jabatan Kesihatan Negeri Pahang
• University Malaya Centre for Addiction Science (UMCAS)
• Fakulti Perubatan Universiti Kebangsaan Malaysia

Community Services

• Students’ visit and service to the centres through Drug Abuse Course.
• Providing educational and training module on SUD.
• Providing educational and training module to NADA personnel (knowledge transfer). 

Research Grant

• RAGS/1/2014/SKK02/UIAM//1 (80,000) 

 A feasibility study of a clinical trial protocol for the administration of ibogaine as an anti-addictive treatment in patients with opioid use disorder.

• RAGS12-025-0025 (RM40,000) 

Sintesis analog dan modifikasi struktur mitragynine untuk mengkaji perkaitan di antara stuktur mitragynine dengan kesan psikoaktif drug.

• FRGS14-149-0390 (RM89,000) 

Synthesis and Mechanistic Evaluation of Orvinol Analogues as Potential Anti-Relapse to Morphine/ Methamphetamine Dependence

List of Selected Publications 

• Nor Ilyani Mohamed Nazar. “Ibogaine (Iboga tabernanthe) as a potential anti-addictive treatment in the pipeline: A Review”. International Drug Rehabilitation and Prevention Conference 2014. 16^th-17^th October 2014. Universiti Sains Islam Malaysia, Nilai, Negeri Sembilan.
• Nasir Mohamad, Rusli Ismail, Nor Ilyani Mohamed Nazar, Soo Choon Tan, Hann Liang Sim, Ilya Irinaz Idrus, Nor Hidayah Abu Bakar  (2012)   Variability of plasma methadone concentration in opiate dependents receiving methadone: a personalised approach towards optimizing dose .  In: Toxicity and drug testing.  Intechopen.com, Rijeka, Croatia, pp. 129-142 . ISBN 9789535100041
• Nor Ilyani Mohamed Nazar, Hann Liang Sim , Soo Choon Tan, Rusli Ismail, Ramli Musa, Ahmad Zafri Abu Bakar  (2014).    Daily Clinical Dose (D) poorly predicts trough serum methadone concentration (Ctrough) in patients undergo methadone maintenance therapy with good adherence.   International Journal of Pharmaceutical Science and Health Care, 2 (4).  , 0 pp. 1-9.  ISSN 2249-5738
• Nur Syafinaz Wasli, Irna Elina Ridzwan, Marwan Saad Azzubaidi, Abdul Razak Kasmuri, Qamar Uddin Ahmed, Long Chiau Ming, Nornisah Mohamed (2017). Upregulation of kappa opioid receptor system and its association with relapse to morphine/methamphetamine (poly-drug) addiction. Research Journal of Pharmacy and Technology, 10 (12). , 0 pp. 4488-4550. ISSN 0974-3618.
• Irna Elina Ridzwan, Nor Akhi Hijriyati Abdul Rahman, Nur Syafinaz Wasli (2017). The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice. Research Journal of Pharmacy and Technology, 10 (12). , 0 pp. 4488-4550. ISSN 0974-3618.
• Irna Elina Ridzwan, Maryam Saadah Suhaimi, Nur Syafinaz Wasli, Abdul Razak Kasmuri, Marwan Saad Azzubaidi, Ridzwan Hashim, Qamar Uddin Ahmed, …Nornisah Mohamed (2017). Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence. British Journal of Pharmacy, 2 (2). , 0 pp. S21-22S. ISSN 2058-8356.
• Irna Elina Ridzwan, Muhammad Harith Zulkifli, Nur Syafinaz Wasli, Syed Mohd Syahmi Syd Mohmad Faudzi (2016). Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter?. Proceedings of the Medical Research Symposium & Pacific Partnership in conjunction with Kuantan Research Day 2016 International Medical Journal Malaysia, 15 (Supplement issue). , 0 pp. 67-67. ISSN 1823-4631..
• Irna Elina Ridzwan, Maryam Saadah Suhaimi, Abdul Halim Muhamad, Ahmad Jamaluddin Al-Qasami Jusoh, Abdul Razak Kasmuri, Nor Ilyani Mohamed Nazar, Ridzwan Hashim (2014). Evaluating the potential of buprenorphine to reduce relapse to morphine/methamphetamine addiction. Malaysian Journal of Pharmacy, 1 (11). , 0 pp. 199-199. ISSN 1675-3666..
• Vinod Kumar, Irna Elina Ridzwan, Stephen M Husbands, Konstantinos Grivas, John W Lewis, Mary J Clark, Claire Meurice, …Irina Pogozheva (2014). Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity. Journal of Medicinal Chemistry, 57. , 0 pp. 4049-4057. ISSN 0022-2623.

• Sarah F Cordery, Alistair Taverner, Irna Elina Ridzwan, Richard H Guy, M Begoña Delgado-Charro, Stephen M Husbands, Christopher P Bailey (2014). A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm. Addiction Biology, 19 (4). , 0 pp. 575-586. ISSN 1355-6215.
• Irna Elina Ridzwan, Mary Clarke, J. Traynor, Stephen M Husbands, Christopher P Bailey (2012). A single compound alternative to A Buprenorphine/Naltrexone combination to prevent relapse to drug addiction. British Journal of Clinical Pharmacology, 73 (6). , 0 pp. 1004-1004. ISSN 0306-5251.
• Irna Elina Ridzwan, Maryam Saadah Suhaimi, Abdul Halim Muhamad, Abdul Razak Kasmuri, Nor Ilyani Mohamed Nazar, Ridzwan Hashim, Syed Mohd Syahmi Syd Mohmad Faudzi. Low-Dose Methamphetamine Addiction Induced Opioid Receptor Sensitization in Polydrug-Dependent Mice. Regional Conference on Science, Technology and Social Sciences (RCSTSS 2016). Chapter 59. p613-624. Springer-International

Background

Quality Use of Medicines (QUM) refers to the selection of suitable therapeutic interventions followed by assuring the safe and cost-effective use of medicines. The World Health Organization have identified improved patient safety in healthcare as a priority. Pharmacists, in particular, have a key role in ascertaining the quality of medications used for patients, especially in vulnerable populations and patients with chronic diseases. Our research group is more practice-oriented that covers all aspects of quality use of medicines. The current research involves but not limited to the use of medicines in geriatrics and patients with diabetes, cardiovascular diseases, infectious diseases, and psychiatric illness. 

Scope of Research Activities

1. To assess the quality of use and prescribing of medicines.
2. To investigate the barriers and facilitators towards QUM.
3. To conduct interventional studies to improve QUM.
4. To promote and assess the awareness towards medication adherence, medicines information sources and health literacy.
5. To investigate and assess pharmacists’ competencies, education and training related to QUM.

Leader and Members

• Asst. Prof. Dr. Mohamed Hassan Elnaem (Leader)
• Asst. Prof. Dr. Muhammad Eid Akkawi
• Asst. Prof. Dr. Abdul Rahman Fata Nahas
• Asst. Prof. Dr. Nor Hidayah Mohd Taufek
• Asst. Prof. Dr. Nor Ilyani Mohamed Nazar
• Asst. Prof. Dr. Norny Syafinaz Ab Rahman
• Asst. Prof. Dr. Siti Hadijah Binti Shamsudin
• Asst. Prof. Dr. Abdulkareem Mohammed Al-Shami
• Asst. Prof. Dr. Tengku Karmila Tengku Kamil

Post graduate students

Open for recruitment

Laboratory(s) and Facility(s) 

• Pharmacy practice laboratory and discussion room

Link and Collaboration

• Department of Pharmacy, IIUMMC.
• Department of Internal Medicine, Kulliyyah of Medicine, IIUM.
• Department of Family Medicine, Kulliyyah of Medicine, IIUM.
• AP. Dr. Hasniza Zaman Huri, Department of Pharmacy, University of Malaya
• Dr. Noordin Othman, QUMPRG, Department of Clinical and Hospital Pharmacy, Taibah University, Saudi Arabia.

Community Services

• Conduct home-medication review (HMR) for elderly patients Campaign to improve health literacy among the public focusing on cardiovascular disease prevention, diabetes and mental health.

Research Grant

• Improving the Quality Use of the Prescribed Pharmacotherapy for Patients with Chronic Diseases : A Multifaceted Approach, 2020.
• Evaluation of the factors associated with lipid-lowering therapy use among patients with type 2 diabetes mellitus and the impact of academic detailing.”, 2017.
• Evaluation of lipid-lowering therapy use among patients with type 2 diabetes mellitus in Pahang”, 2016.
• Development and Assessment of a Smartphone Application to Help Healthcare Providers Avoid Potentially Inappropriate Prescribing Among Hospitalized Elderly Patients, 2015.

List of Selected Publications

• Elnaem MH, Nik Mohamed MH, Zaman Huri H, Azarisman SM. Effectiveness and prescription pattern of lipid-lowering therapy and its associated factors among patients with type 2 diabetes mellitus in Malaysian primary care settings. Ther Clin Risk Manag. 2019; 18: 137–145.
• Akkawi ME, Nik Mohamed MH, Md Aris MA, Does inappropriate prescribing affect elderly patients’ quality of life? a study from a Malaysian tertiary hospital. Qual Life Res. 2019.
• Akkawi ME, Nik Mohamed MH, Are physicians and clinical pharmacists aware and knowledgeable enough about inappropriate prescribing for elderly patients? Findings from Malaysia. Eur J Hosp Pharm. 2018; 25, e29-e34.
• Elnaem MH, Nik Mohamed MH, Zaman Huri H, Azarisman SM. Impact of educational outreach intervention on enhancing health care providers’ knowledge about statin therapy prescribing in Malaysian patients with type 2 diabetes mellitus. J Eval Clin Pract. 2018; 24: 521–527.
• Akkawi ME, Nik Mohamed MH, Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community. Trop J Pharm Res. 2018; 17(1):151-160.
• Elnaem MMH, Nik Mohamed MMH, Huri HZ, Azarisman SM. Patterns of statin therapy prescribing among hospitalized patients with Type 2 diabetes mellitus in two Malaysian tertiary hospitals. Trop J Pharm Res. 2017; 16: 3005–3011. 
• Elnaem M, Nik Mohamed M, Huri HZ, Azarisman SM, Elkalmi RM. Statin therapy prescribing for patients with type 2 diabetes mellitus: A review of current evidence and challenges. J Pharm Bioallied Sci. 2017; 9: 80.

Background

Research methodology is the overall plan ‘that shapes our choice and use of particular methods and links them to the desired outcomes’. Qualitative research is complementary in evaluating the in-depth standpoints and diverse opinions of healthcare practitioners on patient safety, patient advocacy and patient centered care. Qualitative research imparts more flexible meaning, generally emerge from stakeholders’ direct experiences either from their daily lives or professional practices. 

Scope of research activities

1. Rigor in Qualitative Research Instrument
2. Patient- Centered Care through Action Research
3. Patient Safety through Social Phenomenological Approach
4. Cultural Competence in Healthcare through Participatory Action Research
5. Stakeholders Observation on Quality of Life in Patients having Non-communicable Diseases

Leader and members

• Asst. Prof. Dr. Syahrir bin Zaini (Leader)
• Asst. Prof. Dr. May Khin Soe 

Post graduate students

• Mohemmad Redzuan bin Mohemmad Rizal (PPHAR)
• Nurul Aziera Binti A Rahim (MPHA)

Laboratory(s) and Facility(s)

• Space (Required)
• Computer-Desktop (Required)
• Voice Recorder, Video Recorder, Transcription Software with Foot pedal Transcribe. MAXQDA, Diarium (Available with the leader)

Link and Collaboration

• Dr Shubashini Gnanasan and Dr Mahmathi Karuppannan, Faculty of Pharmacy (Puncak Alam Campus), Universiti Teknologi MARA Selangor, Malaysia
• Prof Mohd Makmor Bakry, Fakulti Farmasi, UKM
• Prof Zaheer Babar, Director Pharmaceutical Policy and Practice Center, Department of Pharmacy, University of Huddersfield, United Kingdom
• Dr Maryam Farooqui, Pharmacy Practice, Unaizah College of Pharmacy, Qassim University, Buraydah, Saudi Arabia
• Prof Madeeha Malik, Dir. Pharm Pract, Hamdard University, Islamabad, Pakistan
• Prof Tazeen Saeed Ali, School of Nursing, Aga Khan University, Karachi, Pakistan

Community Services

• To disseminate the results of community based participatory action research to participants.
• To provide feedback to the community through public forum and establish mutually beneficial partnership.

Research Grants

• RIGS15-097- 0097 Prescribing Patterns and Factors Associated with Compliance to Diabetes Selfcare Behaviors and Glycemic Control Among Pakistani And Malaysian People with Type 2 Diabetes Mellitus
• Grant Amount 20,000 RM
• Status-Principal Investigator
• Duration-15^th December 2015-18^th September 2017

• Project ID EDW B 13-086-0971
• Qualitative and Quantitative analysis of Generic medicines’ perception among future pharmacy practitioners: A nationwide study
• Grant Amout-20,000 RM
• Status-Principal Investigator
• Duration-March 2014-March 2015
• Project Id No BPharm B01/10-Res (19)2013
• Attitude of Malaysian Pharmacy Students towards Antibiotic Usage and Resistance Mechanism-A Quantitative Insight
• Grant Amount- RM 13,800
• Status-Co Investigator 
• Duration-July 2013-December 2015

List of Selected Publications

• Doa Alkhalidi, Shazia Qasim Jamshed, Ramadan Elkalmi, Mirza Rafi Baig, Mohamed Azmi Hassali. General Public Views, Attitudes, and Experiences toward Drug Safety in Dubai, United Arab Emirates: A Qualitative Approach. Pharmacy 2019, 7, 19.
• Eman Dyab, Ramadan Elkalmi, Siti Halimah Bux, Shazia Qasim Jamshed. Exploration of Nurses’ Knowledge, Attitudes, and Perceived Barriers towards Medication Error Reporting in a Tertiary Health Care Facility: A Qualitative Approach. Pharmacy. 2018; 6(4):120.
• Atta  Abbas Naqvi^, Mohamed Azmi Hassali^, Mehwish Rizvi, Ale Zehra, Wajiha Iffat, Abdul Haseeb, Shazia Jamshed. Development and validation of a novel General Medication Adherence Scale (GMAS) for chronic illness patients in Pakistan. Frontiers in Pharmacology doi: 10.3389/fphar.2018.01124 https://www.frontiersin.org/articles/10.3389/fphar.2018.01124/abstract
• Shazia Qasim Jamshed, Mohammad Jamshed Siddiqui, Bareera Rana, Akshaya Srikanth Bhagavathula. Evaluation of the involvement of pharmacists in diabetes self-care: A review from the economic perspective. Frontiers in Public Health 2018, 6.
• Sakeena Hameem, Alexandra A. Bennett, Shazia Jamshed, Fahim Mohamed, Dilanthi R. Herath, Indika Gawarammana6 and Andrew J. McLachlan. Investigating knowledge regarding antibiotics and antimicrobial resistance among pharmacy students in Sri Lankan universities BMC infectious diseases 2018 18:1
• Akash Syed, Saira Azhar, Muhammad Mohsin Raza, Humaira Saeed, Shazia Qasim Jamshed. Knowledge, Attitude and Barriers towards Pharmacovigilance among Physicians and Pharmacists of Abbottabad, Pakistan. Pharmacy 2018, 6 (2), 29.
• Peter Bai James, Abdulai Jawo Bah, Emmanuel Kamanda Margao, Christian Hanson, John Alimamy Kabba, Shazia Qasim Jamshed. Exploring the Knowledge and Perception of Generic Medicines among Final Year Undergraduate Medical, Pharmacy, and Nursing Students in Sierra Leone: A Comparative Cross-Sectional Approach. Pharmacy 2018, 6(1):3.
•  

THEMATIC ANALYSIS TRAINING

SLIDES FOR THEMATIC ANALYSIS TRAINING.pptx

SAMPLE DATABASE

EDITED RESPONSE CSSFS.xlsx

Background

Toxicology is an integrated discipline that focuses on effects of xenobiotics to living creatures and environment. The group core strength will be mechanistic toxicology on natural toxins, commonly used herbs and conventional drugs. The group will employ traditional toxicology techniques as well molecular techniques to elucidate mechanism of toxicities. 

Scope of research activities 

i.   Isolation and characterization of venom and toxins.

ii.  Proteomic study of venom and toxins.

iii. Neurotoxicity and cardiotoxicity studies for venom and toxins.

iv.  Nephrotoxicity studies of drug-drug, drug-herbal interactions.

Leader and members

1. Assoc. Prof. Dr. Abdul Razak Kasmuri.
2. Asst. Prof. Dr. Muhamad Rusdi Ahmad Rusmili.
3. Asst. Prof. Dr. Che Anuar Che Muhammad.
4. Asst. Prof. Dr. Rosazra Roslan.
5. Asst. Prof. Dr. Nurul Asyiqin Yusof.
6. Asst. Prof. Dr. Zalikha Ibrahim.

Post graduate students: (as main supervisor)

a. On-going (as main supervisor or chairman)

i. Ph.D students:

• Asyikin Zulkifli . Thesis title: Pharmacological Characterization of Toxins from Malaysian monocled cobra (Naja kaouthia) and equatorial spitting cobra (Naja sumatrana)

b. Graduated  (as main supervisor or chairman)

 None

Laboratories and facilities

General laboratory at Department of Basic Medical Sciences.

• Link and collaboration:

• Prof. Iekhsan Othman (Monash University Malaysia)
• Dr. Ahmad Khaldun Ismail (UKMMC)
• Major Dr. Janeyuth Chaisakul (Phramongkutklao College of Medicine, Thailand)
• Dr. Tri Maharani (Toxinology Society of Indonesia)

Community services

• Seasonal project depending on jellyfish seasonal and migration pattern in Kuantan water. The focus will be on prevention of serious effect caused by jellyfish sting and application of the correct first aid to victim.
• Insect bites awareness project to educate local community on insect bites

Research Grant (on going)

• Characterization of Green Pit Viper Venoms RIGS (17-007-0582)
• Characterization Of Neuromuscular And Cardiovascular Effects Of Non-conventional Three Finger Toxins From Malaysian Spitting Cobra (Naja sumatrana) Venom (FRGS19-040-0648)

List of selected publications

• Zainal Abidin SA, Rajadurai P, Chowdhury ME, Ahmad Rusmili MR, Othman I, Naidu R. Cytotoxic, Antiproliferative and Apoptosis‐inducing Activity of L‐Amino Acid Oxidase from Malaysian Calloselasma rhodostoma on Human Colon Cancer Cells. Basic & clinical pharmacology & toxicology. 2018 Nov;123(5):577-88.
• Charoenpitakchai M, Wiwatwarayos K, Jaisupa N, Rusmili MR, Mangmool S, Hodgson WC, Ruangpratheep C, Chanhome L, Chaisakul J. Non-neurotoxic activity of Malayan krait (Bungarus candidus) venom from Thailand. Journal of Venomous Animals and Toxins including Tropical Diseases. 2018 Dec;24(1):9.
• Rusmil MR, Othman I, Mohamad CA. The Use of Venom and Venom-Derived Products in Medicine and Cosmetics: the Ethical Issues From Islamic Perspective. International Medical Journal Malaysia. 2018 Apr 2;17.
• Chaisakul J, Rusmili MR, Hodgson WC, Hatthachote P, Suwan K, Inchan A, Chanhome L, Othman I, Chootip K. A pharmacological examination of the cardiovascular effects of Malayan krait (Bungarus candidus) venoms. Toxins. 2017 Apr;9(4):122.
• Zainal Abidin S, Rajadurai P, Chowdhury M, Ahmad Rusmili M, Othman I, Naidu R. Proteomic characterization and comparison of Malaysian Tropidolaemus wagleri and Cryptelytrops purpureomaculatus venom using shotgun-proteomics. Toxins. 2016 Oct;8(10):299.

Pharmaceutics and Translational Research Group

Background

Pharmacy is a dynamic discipline of science that its area is attributed to both fundamental and applied research including physical and organic chemistry, engineering, biology, biochemistry, pharmacotherapy, and pharmacology.

The combination of disciplines, resources, expertise, and techniques should be established to endorse developments of pharmaceutical products from bench to bedside. The research group is aimed to integrate the pharmaceutics and pharmacology in one pool of expertise.

Theme

“Bringing research from the bench to bedside”

Objectives: 

• To form a pool of researchers with diverse expertise enabling complementary researches in pharmaceutical development and production;
• To promote researches addressing emerging problems in pharmaceutical development and production with the ultimate aim of improving quality of life; and
• To provide scientific support to fledging pharmaceutical products through preclinical and clinical study.

Research coverages 

1. Nanoparticles formulation.
2. Drug delivery.
3. Drug crystallisation.
4. Natural product developments.
5. Formulation technology
6. Bioassay techniques.
7. Clinical study.

List of members 

• Dr. Muhammad Taher Bakhtiar, Scopus ID: 57201790510 (Head)
• Prof. Dr. Farahidah Mohamed, Scopus ID: 57190849648
• Prof. Dr. Hazrina Ab Hadi, Scopus ID: 56388473000
• Prof. Dr. A. B. Mohammad Helaluddin, Scopus ID: 55901129500
• Prof. Dr. Mohd Rushdi Abu Bakar Scopus, ID: 55966965200
• Prof. Dr. Juliana Md Jaffri Scopus, ID: 38561428200
• Prof. Dr. Muhammad Salahuddin Haris, Scopus ID: 57104948200
• Siti Hadijah Shamsuddin, Scopus ID: 56684987400
• Awis Sukarni Mohmad Sabere, Scopus ID: 55930141700
• Muhammad Taufiq bin Mohd Jaelani, Scopus ID: 58478718300

Recent publications

1. Taher Bakhtiar, Deny Susanti Darnis, Muhammad Salahuddin Haris, Aina Atiqah Rushdan, Riyanto Teguh Widodo, Yandi Syukri, Junaidi Khotib (2023). PEGylated liposomes enhance the effect of cytotoxic drug: A review. Heliyon, 9 (3). pp. 1-13.
2. Nur Afifah Mohd Zulkafly, Deny Susanti Darnis, Tengku Karmila Tengku Kamil, M. Taher Bakhtiar (2023). Silver nanoparticle biogenically synthesised by Psychotria malayana Jack: physicochemical, cytotoxic and antimicrobial characterisations. Journal of Pharmacy, 3 (2). pp. 140-153.
3. Amri Nurhakim Mat Husin, Nurul Atifah Azmi, Nurul Hanis Mohd Sabari, Mohamad Haniki Nik Mohamed, Nurul Ain Mohammad Hamdi, Muhammad Salahuddin Haris (2023). A systematic review on effectiveness of Nicotine-Based and Non-Nicotine Based drug delivery system for smoking cessation among the elderly. Malaysian Journal of Medical and Health Sciences, 19 (1). pp. 232-241.
4. Siti Hajar Ahmad Shariff, Rusli Daik, Muhammad Salahuddin Haris, Mohamad Wafiuddin Ismail (2023). Hydrophobic drug carrier from polycaprolactone-b- poly(ethylene glycol) star-shaped polymers hydrogel blend as potential for wound healing application. Polymers, 15 (9). pp. 1-22.
5. Muhammad Fitri Azhar, Nurul Ain Mohammad Hamdi, Muhammad Salahuddin Haris (2023). Stability study of royal jelly in alginate-pectin beads. Journal of Pharmacy, 3 (1). pp. 38-52.
6. Nurul Ain Mohammad Hamdi, Nurul Atifah Azmi, Nurul Hanis Mohd Sabari, Ahmad Fahmi Harun @ Ismail, Muhammad Salahuddin Haris (2023). An insight into the use and advantages of Carbopol in topical mucoadhesive drug delivery system: A systematic review. Journal of Pharmacy, 3 (1). pp. 53-65.

6. Nur Suhaila Sudarman, Muhammad Salahuddin Haris (2023). Spectrophotometric simultaneous analytical method validation to determine isoniazid and pyridoxine in pure and 3D printed tablet forms. Journal of Pharmacy, 3 (1). pp. 9-18.
7. Nurul Ain Mohammad Hamdi, Ahmad Fahmi Harun Ismail, Muhammad Salahuddin Haris, Widya Lestari (2023). Ascorbic acid-loaded poly(lactic-co-glycolic acid) nanoparticles incorporated into a polyacrylic acid gel as a promising tool for site- specific oral cancer Thai Journal of Pharmaceutical Sciences, 46 (6). pp. 696- 710.
8. Hamzeh Alkhatib, Farahidah Mohamed, Awis Sukarni Mohmad Sabere, Hazem Choukaife, Abd Almonem Doolaanea (2023). Emulsification-assisted spectroscopic analysis of black seed oil in alginate beads: method development and validation. Analytical Chemistry Letters, 13 (3). pp. 1-10.
9. Nor Hidayah Mohd Taufek, Awis Sukarni Mohmad Sabere, Ummi Syahidah Mohamad Jamahari, Nur Balkhis Amran, Abdul Rahman Fata Nahas, Joseph Bidai (2023). Determination of zinc, copper, selenium, and manganese in human milk using acid digestion by ICP-MS and its application in biological trace element Journal of Pharmacy, 3 (2). pp. 129-39.
10. Mahmudul Hasan, Qamar Uddin Ahmed, Jalifah Latip, Siti Zaiton Mat So’ad, Muhammad Taher, Awis Sukarni Mohmad Sabere, Zainul Amiruddin Zakaria (2023). An in vitro Adipogenic Potential and Glucose Uptake Stimulatory Effect of Betulinic Acid and Stigmasterol Isolated from Tetracera indica in 3T3-L1 Cell Line. Sains Malaysiana, 52 (2). pp. 501-512.
11. Tariqul Islam, B.M. Helal Uddin, Sahena Ferdosh, Md. Zaidul Islam Sarker (2022). Measurement of solvent properties using kamlet-taft approach for application in synthesis. Malaysian Journal of Analytical Science, 26 (1). pp. 39-46. ISSN 13942506
12. Tariqul Islam, Zaidul Islam Sarker Sarker, A.B.M. Helal Uddin, Richard Smith Jr Lee (2022). Acetaminophen synthesis and encapsulation using safe mixed-solvents and solution enhanced dispersion by supercritical CO2. The Journal of supercritical fluid, pp. 1-9. ISSN 0896-8446
13. Kai Bin Liew, Shou Hui Hii, B.M. Helal Uddin, Zaidul Islam Sarker, Yik Ling Chew (2022). Co-processed excipients: a revisit of its development in the past two decades; a review. Journal of Pharmaceutical Negative Results, 13 (7). pp. 96-103. ISSN 0976-9234
14. AishaAshiq,SaleemJan,YarMuhammadKhan,FaizanUllah,AshokKumarBalaraman,AbulKala mAzad,TanveerAhmadKhan,A.B.M.HelalUddin(2023) HypoglycemicandhypolipidemiceffectsofOligomerislinifoliainAlloxan-induceddiabeticmice vol.17(2)901-906, ISSN 2230-7303.

List of MOU

1. Universitas Muhammadiyah Jakarta
2. Fukuoka University, Japan

Awards: 

Intellectual properties:

Copyright

1. 5% Flaxseed Oil Ointment (CRLY2022W03237)
2. Encapsulation of Malaysian patin oil-loaded alginate microbeads prototype for supporting children’s growth (CRLY2022W05584)

Patent Filing

1. Catfish Fish Oil Production Method, Catfish Fish Oil, and Assembly Thereof (PI 2023004427)

Utility innovation

1. CENTELLA ASIATICA HYDROGEL SHEET FOR WOUND DRESSING (UI2021007805)

Grant received:

Keynote/Plenary/ Invited speaker.

1. Muhammad Taher. Keynote Speaker, In 3^rd Annual International Conference on Natural and Social Science Education (ICNSSE), 21-23 June Uhamka Jakarta. Title: Translational Science in Drug Development. https://conference.uhamka.ac.id/icnsse/#speakers
2. Awis Sukarni Mohmad Invited speaker, in International Conference on Smart Nanotechnologies (ICONSNT), 6-8 July 2023. Gitam University. https://www.iconsnt.smartnanosolutions.qa/speakers

Consultancy 

1. Economic Empowerment Project for Single Mothers and Housewives from B40 Families through a Sustainable Community-based Stingless Bee Project of Desa Kelulut (RM 253148.76) (2023) (Yayasan Hasanah)
2. C22-243-0561 (Biopharma Inc)

Conference organised 

1. International conference on Pharmaceutical Sciences, 2022 8-9 August 2022, Online conference.

https://www.iium.edu.my/announcements/international-conference-on- pharmaceutical-sciences-icopsatiium-2022

2. International conference on Pharmaceutical Sciences, 2022 18-19 May, 2023, Putrajaya https://conference.iium.edu.my/icops2023/

Background

Big data in healthcare refers to electronic health data sets that are so large and complex that it would be difficult to manage and analyze using traditional software and data management tools and methods. Big data in healthcare is also known as large health care databases which is one of the sources for drug utilization study. It is often used to address research questions on drug use and drug effect such as evaluation of the processes of prescribing, dispensing and consumption of medicines to improve the quality use of medicines in populations.

Large healthcare databases, which contain data collected during routinely delivered healthcare to patients, can serve as a valuable resource for generating actionable evidence to assist in medical and healthcare policy decision-making. The sources of large healthcare data include electronic medical records, health insurance claims and patient registries. Data may be collected on drug sales, prescriptions, drug distribution chain, pharmaceutical and medical billing. The scope of the databases may be international, national or local. The databases may be diagnosis-linked or non-diagnosis-linked. Diagnosis-linked data enable drug use to be analyzed according to patient characteristics, therapeutic groups, diseases or conditions and, in the best of cases, clinical outcome. A useful analysis requires an understanding of the sources and organization of the data.

Harnessing the power of information contained in large healthcare databases, while paying close attention to their inherent limitations, is critical to generate rigorous evidence-base for medical decision-making and ultimately enhancing patient care.

Scope of Research Activities

1. Data mining for healthcare database study
2. Patient level drug utilization
3. Advance statistical methods
4. Modeling for clinical outcomes

Leader and Members

• Assoc. Prof. Dr. Che Suraya Binti Mohd Zin (Leader).
• Asst. Prof. Dr. Norny Syafinaz Ab Rahman.
• Asst. Prof. Dr. Nor Ilyani Mohamed Nazar.
• Asst. Prof. Dr. Nor Hidayah Mohd Taufek.
• Mdm Nor Elina Alias.

Post graduate students

• Hosam Jabar, PhD.
• Asween Rowena, PhD. 
• Nor Elina Alias, PhD.

Laboratory(s) and Facility(s) 

• STATA

Link and Collaboration

• My Health Data Warehouse (MyHDW).
• Pharmacy and Medical Databases Hospital Selayang and Hospital Sultanah Nur Zahirah.
• Professor Lisa Nissen, The Queensland University of Technology, Australia.
• Professor Patrick Ball, The University of Wolver Hampton, United Kingdom.

Community Services

• Not applicable.

Research Grant

• FRGS 19 0100618  RM 126500 Pattern analyzer on concomitant use of opioid and benzodiazepine in patients with chronic non-cancer pain: The rising of opioid overdose death (Principal researcher).
• FRGS 15 1950436  RM114000 Predicting the long term effects and the risks of abuse and misuse in long term opioid users with chronic non-cancer pain (Principal researcher).

List of Selected Publications

• Zin, Che Suraya, Mohamed Nazar, Nor Ilyani, Ab Rahman, Norny Syafinaz   Ahmad, Wan Rohaidah and   Ng, Kim Swan and  (2019) Patterns of initial opioid prescribing and its association with short and long-term use among opioid naïve patients in Malaysia: a retrospective cohort study. BMJ Open (Revision) (ISI indexed impact factor 2.4)
• Zin, Che Suraya, Alias, Nor Elina, Tuafek, Nor Hidayah and Ahmad, Mazlila Meor (2019)  Sex Differences in High Opioid Dose Escalation among Malaysian Patients with Long Term Opioid Therapy. Journal of Pain Research (Minor revision) (ISI indexed impact factor 2.6)
• Asween Rowena Sani, Che Suraya Zin, Abdul Hadi Mohamed, Munira Izat, Tan Hung Ling, Ng Kim Swan and Lisa Nissen (2019) Exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period. Journal of Pharmacy Practice and Research (Minor revision)  
• Zin, Che Suraya and Mohamed Nazar, Nor Ilyani and Ab Rahman, Norny Syafinaz and Alias, Nor Elina and Ahmad, Wan Rohaidah and Rani, Nurul Sahida and Cardosa, Mary Suma and Ng, Kim Swan and Ye, Felicia Loh (2018) Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used. Journal of Pain Research, 11. pp. 1959-1966. ISSN 1178-7090 (ISI indexed impact factor 2.6)
• Mizher, Hussam A,  Zin, Che Suraya,  Abdullah Sani, Asween Rowena, Mohamed, Abdul Hadi, Tan, H Ling and M. Izat, Munira (2018) Adherence to opioid therapy in patients with chronic non-cancer pain attending a pain clinic in Malaysia. Asian Journal of Pharmaceutical and Clinical Research, 11 (Special Issue 3). pp. 4-7. ISSN 0974-2441 (Scopus indexed)
• Zin Che Suraya, Fadhilah Ismail, Co-prescription of opioid with benzodiazepine and other co-medications among opioid users: Differential in opioid doses. Journal of Pain Research 2017:10 249–257 (ISI indexed impact factor 2.36) 
• Zin Che Suraya, Norny Abdul Rahman; Che Rokiah Ismail, Leong Weng Choy. Dose and Duration of Opioid Use in Patients with Cancer and Noncancer Pain at an Outpatient Hospital Setting in Malaysia. Pain Practice 2016 Sep 27 (ISI indexed impact factor 2.42)
• Zin Che Suraya,  Li-Chia Chen, Roger D Knaggs (2014). Changes in trends and pattern of strong opioid prescribing in primary care. European Journal of Pain 18 (2014). ISSN 1532-2149 (ISI indexed impact factor 3.2)

Background

DRG is a focal point for all groups interested in skin biology and the delivery of actives in skin. DRG we will be conducting studies on topical and transdermal compound delivery, skin biology and skin tissue engineering for pharmaceutical and cosmeceutical applications. The group not only will use chemicals as active ingredients in the formulations, but also will do extraction to isolate and characterised potential bioactive compounds for skin applications. The bioactive compounds will also undergo metabolite profiling in order to identify the responsible compounds for its pharmaceutical and/or cosmeceutical activities. Different biophysical techniques will be used to probe the mechanisms of skin penetration and modulation of the active ingredients. Cutting edge technologies and delivery systems such as microspheres, nanosponges, hydrogel will be used to ensure the actives can exert their activities to the target sites. Our current performance is indicated as follows.

Scope of Research Activities

1. Isolation, characterisation and metabolite profiling of bioactive compounds with potential dermatology applications
2. Rational design of formulations for skin formulations
3. Probing the action of penetration modulating agents 
4. Optimisation and characterization of the formulations 
5. Elucidating the activities of the bioactive and/or skin formulations in in-vitro 
6. Assessment of the formulation efficacy in animal models 
7. Pre-clinical studies of skin formulations 
8. Scale up of the formulations

Leader and Members

• Assoc. Prof. Dr. Hazrina Ab Hadi (Leader – Kulliyyah of Pharmacy) 
• Prof. Zaidul Sarker (Kulliyyah of Pharmacy)
• Assoc. Prof. Dr. Alfi Khatib (Kulliyyah of Pharmacy) 
• Assoc. Prof. Dr. Norazian bt Mohd Hasan (Kulliyyah of Pharmacy)
• Assoc. Prof. Dr. Abdul Razak Kasmuri (Kulliyyah of Pharmacy)
• Asst. Prof. Dr Abd Monem Doolaanea (Kulliyyah of Pharmacy)
• Asst. Prof. Dr. Mohd Azri Abd Jalil (Kulliyyah of Nursing)

Post Graduate Students (as Main Supervisor)

a. On-going (as main supervisor or chairman)

i. Ph.D students:

• Noor Shimariza Ashikin Binti Wan Hussin (G1820970). Thesis title: Development of resiquimod loaded nanosponges based topical gel formulation for actinic keratosis treatment. Supervisor: Assoc. Prof. Dr. Hazrina Ab Hadi
• Sharifah Shakirah Binti Syed Omar (G1921638). Thesis title: Fabrication of nanosponges for topical delivery of retinoic acid for skin acne. Supervisor: Assoc. Prof. Dr. Hazrina Ab Hadi.
• Nipun Tanzina Sharmin (G1710044). Thesis title: Evaluation of anti-diabetic activity of Psychotria malayana Jack leaves and characterization of its bioactive compounds using metabolomics and molecular docking simulation. Supervisor: Assoc. Prof. Dr. Alfi Khatib.
• Md. Abdur Rashid Mia (G1817363): Thesis title: Simultanious extraction and fractionation of essential oils from cinnamon using various techniques of supercritical fluid. Supervisor: Prof. Zaidul Sarker
• Tariqul Islam (G1918364). Thesis title: Amide coupling interaction for elimination organic solvent from generic pharmaceuticals with supercritical fluid. Supervisor: Prof. Zaidul Sarker
• Siti Zaleha Binti Raduan (G1828348). Thesis title: The neuroprotective effects of litsea garciae bark extract in zebra fish Alzhemier’s model. Supervisor: Assoc. Prof. Dr Abdul Razak Kasmuri
• Alkhatib Hamzeh (G1822885). Thesis title: Optimization and stability evaluation of pilot scale black seed oil alginate beads formulation. Supervisor: Asst. Prof. Dr Abd Monem
• Md. Abul Kalam Azad (G1629991). Thesis title: Synergic effect of peppermint oil and black seed oil in an animal model of irritable bowel syndrome: Formulation and Efficacy Evaluation. Supervisor: Asst. Prof. Dr Abd Monem
• Nur Ain Binti Ayob (G1614796). Thesis title: Gene therapy of colon cancer using SIRNA encapsulated in nanoparticles. Supervisor: Asst. Prof. Dr Abd Monem
• Nur `Abidah Binti Mohamed Nasir (G1828104). Thesis title: Process analytical technology based approaches for continuous manufacturing of nigella sativa oil-alginate microparticles (NSO-Alg MPs). Supervisor: Asst. Prof. Dr Abd Monem
• Shaiqah Binti Mohd Rus (G1822486). Thesis title: Development and validation of electrospray manufacturing process for black seed oil alginate beads. Supervisor: Asst. Prof. Dr Abd Monem

• ii. Master students:

• Mohammad Ghazali Bin Ab Salam (G1636467). Thesis title: Prevalence of microbial contamination study of cosmetic products in Malaysia. Supervisor: Assoc. Prof. Dr. Hazrina Ab Hadi.
• Alallam Batoul (G1816334). Thesis title: Gene editing using crispr plasmid DNA loaded alginate nanoparticles. Supervisor: Asst. Prof. Dr Abd Monem.
• Luqman Muizzuddin Bin Mohd Rosli (G1610697). Thesis title: The formulation of thymoquinone- loaded PLGA nanoparticles and cytotoxicity in malignant melanoma A375 cell lines in vitro. Supervisor: Asst. Prof. Dr Abd Monem.

b. Graduated (as main supervisor or chairman)

i. Ph.D – no.of students:

• Assoc. Prof. Dr. Hazrina -1
• Prof. Zaidul Sarker – 7 
•  Assoc. Prof. Dr. Alfi Khatib – 2 
• Assoc. Prof. Dr. Abdul Razak Kasmuri – 3 
• Asst. Prof. Dr Abd Monem – 1

ii. Master – no.of students:

• Assoc. Prof. Dr. Hazrina – 7
• Prof. Zaidul Sarker – 2 
• Assoc. Prof. Dr. Abdul Razak Kasmuri – 3 
• Asst. Prof. Dr Abd Monem – 3 
• Assoc. Prof. Dr. Alfi Khatib – 2 
• Assoc. Prof. Dr. Norazian Mohd Hasan – 4

Laboratories and Facilities

a. Laboratories: Pharmacokinetics Lab, Dosage Design Lab, Advanced Drug Delivery Lab, Analytical Chemistry Research Lab 2, Tissue Culture Lab, Herbal Lab. 

b. Facilities: Franz diffusion cells set-up, Dermalab Combo, Freeze dryer, FTIR, Analytical and Preparative HPLC, UV-Vis

Link and Collaboration

• MOA with Hannan Medispa Sdn Bhd

Community Services 

• Education on using natural products in daily skin care routine
• Education on using safe cosmetic products to avoid adverse effect

Target group : IIUM communities

Research Grant (as PI-on going)

• FRGS19-092-0701. Probing the cellular and molecular mechanisms of skin barrier repair in atopic dermatitis by Benincasa hispida seed extract. Amount: RM 180,800 PI: Assoc. Prof. Dr. Hazrina Hadi
• SPP20-009-0009. Fabrication of Nanosponges for Topical Retinoic Acid Delivery for Skin Acne – Phase 1. Amount: RM 50,015. PI: Assoc. Prof. Dr. Hazrina Hadi 
• FRGS19-002-0610: Research title: Mechanism of amide coupling interaction for eliminating organic solvent from generic pharmaceuticals with supercritical CO2 Amount: RM 123,000. PI: Prof Zaidul Sarker 
• P-RIGS18-027-0027. Identification of alpha-glucosidase inhibitors from P. malayana leaf extract using liquid chomatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking. Amount: RM 20,000. PI: Assoc. Prof. Dr. Alfi Khatib. 
• PRGS19-005-0571. Prototype development of process analytical technology (PAT) continuous production line for Nigella sativa oil (NSO)-alginate microparticles. Amount: RM 116,000 . PI: Asst. Prof. Dr Abd Monem 
• SMF18-001-0001. Black Seed Oil Alginate Beads. Amount: RM 976,750. PI: Asst. Prof. Dr Abd Monem 
• FRGS17-005-0571. Elucidating the anti-cancer mechanism of thymoquinone nanoparticles involving the MAPK signaling pathway in zebrafish xenografts of colonic and melanoma cancers. in vitro & in vivo study. Amount: 93,704.00. PI: Asst. Prof. Dr Abd Monem

List of Selected Publications (1 selected publication for 1 lecturer)

• Hadi, H., Awadh, A. I., Zamli, M., Ai, N. A., & Jamshed, S. (2020). Insight of Malaysian Users of Cosmetic Regarding Cosmetovigilance. Cosmetics, 7(2), 45.
• Razali, M., Zainal, Z., Maulidiani, M., Shaari, K., Zamri, Z., Idrus, M. M., Khatib, A., Abas, F., Ling, Y., Rui, L., Ismail, I. S.Classification of raw stingless bee honeys by bee species origins using the NMR-and LC-MS-based metabolomics approach. Molecules, 23 (9), 1-18 (2018)
• Norazian Mohd Hassan, Nurul Asyiqin Yusof, Amirah Fareeza Yahaya, Nurul Nasyitah Mohd Rozali, Rashidi Othman (2019). Carotenoids of Capsicum fruits: pigment profile and health-promoting functional-attributes. Antioxidants, 8 (10). , 0 pp. 1-25. ISSN 2076-3921
• Mohd Azri Abdul Jalil, Abdul Razak Kasmuri, Hazrina Ab. Hadi (2017). The evaluation of physicochemical and anti-microbial properties of honey based hydrogel. Proceedings of the Malaysia Pharmaceutical Society Conference 2017 Malaysian Journal of Pharmacy, 3 (1 (Supplement)). , 0 pp. 25-25. ISSN 1675-3666
• Mohd Azri Abdul Jalil, Abdul Razak Kasmuri, Hazrina Ab. Hadi (2017). Stingless bee honey, the natural wound healer: a review.   Skin Pharmacology and Physiology, 30. , 0 pp. 66-75. ISSN 1660-5527
• Sukmasari, S., O. A. J. A. Qader, M. N. A. Rahman, M. Ibrahim and A. A. Doolaanea (2018). The release profiles of baccaurea angulata extract from various gelling agents. Journal of Pharmaceutical Sciences and Research 10(1): 45-50.

Drug Discovery and Synthetic Chemistry Research Group

Background 

Organic molecules make up nearly everything around us, including our medicines, clothing, and fuels. Research in pharmaceutical organic chemistry is thus an essential pursuit that can impact many other scientific disciplines. By finding novel methods of building molecular architecture, we can facilitate the discovery of life-saving therapeutics, invention of novel materials, and search for alternative energies. Pharmaceutical Organic Chemistry and Medicinal chemistry disciplines are broad areas until the extent of evaluating the synthesised drugs at the receptor level ex vivo and in vivo. Through the semi-synthesis work, the profiles of the isolated compounds from the natural sources can also be improved. The isolated compounds from the natural sources usually have issues related to their binding affinities and selectivity to the target molecule and pharmacokinetic profiles. Therefore, the semi-synthesis technique can be used to overcome these issues. The medicinal chemistry discipline can also be used to get a correct profile of a potential drug at the receptor level before the synthesis work begins. It is extended to big data analysis to connect bioactivity, metabolites, and drug sources.  

Scope of Research activities:  

• Synthetic Drug Design: Semi-synthesis and synthesis of biological active agents, Structure-activity relationship studies (SAR), Bioactivity and toxicity studies 
• Computational Drug Design: Protein-ligand interaction studies, Molecular dynamics simulations, Quantitative-structure activity relationship (QSAR) 

Research Group Members:

Prof. Dr. Qamar Uddin Ahmed (Leader)

Assoc. Prof. Dr. ABM Helal Uddin

Asst. Prof. Dr. Mohamed Sufian bin Mohd. Nawi

Asst. Prof. Dr. Zalikha Ibarhim

Asst. Prof. Dr. Kamal Rullah