Natural Product

Background of research

Research on natural products is considered an important and effective approach providing a diverse source for drug discovery and development. The field of natural product research and pharmaceutical development of these products related to dentistry is evolving quickly.

This research group places special emphasis on the fundamental and applied biodiversity-based natural product research which aims to screen the natural products from medicinal plants with significant potential use as therapeutic agents and to elucidate the biosynthetic pathways important in phytotherapy.

This group aims to increase the success rate of new therapeutic moieties through innovative drug development from natural products.

  1. Effect of flaxseed on TGF-Β, IL-6, and MMP9 genes expression during wound healing process in rabbits. Open Access Macedonian Journal of Medical Sciences, 11 (A) pp. 41-46 ( 2023)
  2. LC-MS/MS-QTOF dataset of compounds detected in kelulut honey of the stingless bees, Heterotrigona itama and Tetrigona binghami from Kuantan, Pahang, Malaysia. Data in Brief, 49 (August 2023) pp. 1-8 ( 2023)
  3. LC-MS/MS-QTOF dataset of compounds detected in kelulut honey of the stingless bees, Heterotrigona itama and Tetrigona binghami from Kuantan, Pahang, Malaysia. Data in Brief, 49 (August 2023) pp. 1-8 ( 2023)
  4. Chemical composition of essential oil from Lindera caesia Reinw. ex Fern.-Vill. and its antifungal, antibiofilm, and molecular docking studies. Natural Product Research, (2023)
  5. Chemical composition of essential oil from lindera subumbelliflora kosterm and its effect on the susceptibility and biofilm activities of candida albicans and streptococcus mutans. Natural Product Research,  pp. 1-6. (2023)
  6. The effect of Salvadora persica ethanolic extract on oral tissue healing in rats: an in vivo study. Saudi Dental Journal, 35 (6) pp. 663-667 (2023)
  7. Antioxidant protective effect of trihoney against hypercholesterolemia-induced testicular oxidative stress in rabbit model. World Journal of Pharmacy and Pharmaceutical Sciences, 12 (3) pp. 1336 -1348 (2023)
  8. Effects of incorporation of Eurycoma longifolia jack root extract on properties of heat cured acrylic resin. Journal of International Oral Health, 15 (4) pp. 404-408 (2023)
  9. Improved quality of healed wounds with topical application of Eurycoma Longifolia Jack root extract hydrogel. IIUM Medical Journal Malaysia, 22 (4) pp. 115-121(2023)
  10. The effects of the topical application of eurycoma longifolia jack (TA) root extract hydrogel on vascular endothelial growth factor (VEGF) expression during wound healing in vivo excisional wound model. IIUM Medical Journal Malaysia, 22 (1) pp. 79-86 (2023)
  11. A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study. International Journal of Food Properties, 26 (1) pp. 1414-1425 (2023)
  12. FTIR fingerprinting profiling, antioxidant activity, and α-glucosidase inhibitory activity of Orthosiphon stamineus leaf ethanolic extracts. International Journal of Food Properties, 26 (1) pp. 2025-2038 (2023)
  13. Phytochemical analysis, antioxidant, α‑glucosidase inhibitory activity, and toxicity evaluation of Orthosiphon stamineus leaf extract. Scientific Reports, 13 () pp. 17012-17025 (2023)
  14. Phytoconstituents assessment and toxicity study of Gelidium spinosum water extract in zebrafish (Danio rerio) embryos. Rasayan Journal of Chemistry, 16 (3) pp. 1883-1891 (2023)
  15. Phytotherapy and oral health. IIUM Journal of Orofacial and Health Sciences (IJOHS), 4 (1) pp. 1-3 ( 2023)
  16. A bibliometric analysis of coconut sap research. Malaysian Journal of Nutrition, 29 (2) pp. 243-253 (2023)
  17. Anti-diabetic properties of traditional herbal concoction containing Eleutherine palmifolia (L.) Merr., Momordica charantia L., and Syzygium polyanthum (Wight.): a bibliometric analysis. Food Production, Processing and Nutrition, 5 () pp. 1-24 (2023)
  18. Anti-MRSA activity of Stereospermum fimbriatum’s stem bark extracted using subcritical and supercritical carbon dioxide. IIUM Journal of Orofacial and Health Sciences, 4 (2) pp. 145-151 (2023)
  19. In vitro and in vivo assessments on nutraceutical and safety of herb-fruit based drink on female Wistar Rats. IIUM Medical Journal Malaysia, 22 (2) pp. 65-73 (2023)
  20. Role of herbal tea (camellia sinensis L. Kuntze, Zingiber officinale Roscoe and Morinda citrifolia L.) in lowering cholesterol level: a review and bibliometric analysis. Journal of Agriculture and Food Research, 13 () pp. 1-11 (2023)
  21. Quantification of chlorophyll content in leaves of avicennia germinans, laguncularia racemosa, durio zibethinus, garcinia mangostana, spinacia oleracea, piper betle, piper sarmentosum and centella asiatica. International Journal of Innovation and Industrial Revolution, 5 (14) pp. 125-132 (2023)
  22. Angiotensin Converting Enzyme (ACE) inhibitionactivity by Syzygium polyanthum Wight (Walp.) leaves: mechanism and specificity. Pharmacognosy Journal, 14 (1) pp. 763-84 ( 2022)
  23. Synbiotic Musa acuminata skin extract and Streptococcus salivarius K12 inhibit candida species biofilm formation. Biofouling, 38 (6) pp. 614-627 ( 2022)
  24. The vascular protective effects of trihoney in hypercholesterolemic atherosclerotic rabbits, a comparative study with atorvastatin. Egyptian Journal of Basic and Applied Sciences, 9 (1) pp. 359-371 (2022)
  25. The effect of Eurycoma longifolia Jack Tongkat Ali hydrogel on wound contraction and re-epithelialization in In Vivo excisional wound model. Macedonian Journal of Medical Sciences, 10 (A) pp. 634-643 (2022)
  26. Antimicrobial activity of β-Sitosterol Isolated from Kalanchoe tomentosa leaves against Staphylococcus aureus and Klebsiella pneumonia. Pakistan Journal of Biological Science, 25 (7) pp. 602-607 (2022)
  27. Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5‑fluorouracil‑induced oral mucositis: an animal study. Journal of Cancer Research and Clinical Oncology, 148 () pp. 1-10 (2022)
  28. Fabrication, physicochemical and rheological characterisation of a drug-therapeutic oils (doxycycline hyclate-nigella sativa-eugenol) complex emulsion stabilised by lecithin and hydroxypropyl methylcellulose intended for delivery into periodontal pocket. Malaysian Journal of Medicine and Health Sciences, 18 (1) pp. 20-28 (2022)
  29. Molecular docking study of naturally derived β- mangostin with antiapoptotic Bcl-2 proteins toward oral cancer treatment. ESTEEM Academic Journal, 18 () pp. 128-138 (2022)
  1. Assoc. Prof. Datin Ts. Dr.Khairani Idah Binti Mokhtar @ Makhtar
  2. Assoc. Prof. Ts. Dr.Mohd Hafiz Bin Arzmi
  3. Assoc. Prof. Dr.  Widya Lestari 
  4. Assoc. Prof. Ts. Dr.Azlini Binti Ismail
  5. Prof. Dr. Nazih Shaban Mustafa
  6. Prof. Dr. Ghasak Ghazi Faisal
  7. Prof. Dr. Zurainie Binti Abllah
  8. Prof. Dr Noorhazayti Ab. Halim
  9. Prof. Dr. Yunita Dewi Ardini
  10. Prof. Dr. Hamad Abdulsalam Hamad Alfarisi
  11. Prof. Dr. Khairul Bariah Binti Chi Adam 
  12. Asst Prof Dr. Pram Kumar Subramaniam
  13. Prof. Dr.Wan Nor Hayati Binti Wan Abd. Manan 
  14. Prof. Dr. Susi Sukmasari
  15. Prof. Dr. Anis Zafirah Binti Mustapa
  16. Prof. Dr .Anis Fadhlina Izyani Binti Awang
  17. Prof. Ts. Dr Mohamad Zakkirun Bin Abdullah

Area of research

  1. Screening natural products from medicinal plants with significant potential use as therapeutic agents.
  2. Development of pharmaceutical products from a natural base.